Publications | Kwon lab@KIST

32. Jueun Sim, Chan E Park, In Cho, Kyeongbae Min, Minho Eom, Seungjae Han, Hyungju Jeon, Eun-Seo Cho, Yunjeong Lee, Young Hyun Yun, Sungho Lee, Deok-Hyeon Cheon, Jihyun Kim, Museong Kim, Hyun-Ju Cho, Ji-Won Park, Ajeet Kumar, Yosep Chong, Jeong Seuk Kang, Kiryl D Piatkevich, Erica E Jung, Du-Seock Kang, Seok-Kyu Kwon, Jinhyun Kim, Ki-Jun Yoon, Jeong-Soo Lee, Cheol-Hee Kim, Myunghwan Choi, Jin Woo Kim, Mi-Ryoung Song, Hyung Jin Choi, Edward S Boyden, Young-Gyu Yoon, Jae-Byum Chang (2025)

Nanoscale Resolution Imaging of Whole Mouse Embryos Using Expansion Microscopy

ACS nano, 2025 Mar 4;19(8):7910-7927. doi: 10.1021/acsnano.4c14791. Epub 2025 Feb 18.

31. JunYoung Choi, Hyun-Jic Oh, Hakjun Lee, Su Yeon Kim, Seok-Kyu Kwon, Won-Ki Jeong (2023)

MitoVis: A Unified Visual Analytics System for End-to-End Neuronal Mitochondria Analysis

IEEE Transactions on Visualization and Computer Graphics, 2023 Jan 2; DOI: 10.1109/TVCG.2022.3233548

30. Su Yeon Kim†, Klaudia Strucinska†, Bertha Osei†, Kihoon Han, Seok-Kyu Kwon* and Tommy L. Lewis Jr.* (2022) (†co-first author, * co-corresponding author)

Neuronal mitochondrial morphology is significantly affected by both fixative and oxygen level during perfusion

Front. Mol. Neurosci., 02 November 2022; https://doi.org/10.3389/fnmol.2022.1042616

29. Taeseong Woo, Hye Yun Kim, Su Yeon Kim, Byungjae Hwang, Cheolwoo Ahn, Seok-Kyu Kwon, Jae-Ick Kim, and Jung-Hoon Park (2022)

High-throughput high-dynamic range imaging by spatiotemporally structured illumination

APL Photonics 7, 106106 (2022); https://doi.org/10.1063/5.0099780

28. Ruiying Ma, Kaifang Pang, Hyojin Kang, Yinhua Zhang, Geul Bang, Sangwoo Park, Eunha Hwang, Jae Ryun Ryu, Yujin Kwon, Hyae Rim Kang, Chunmei Jin, Yoonhee Kim, Su Yeon Kim, Seok-Kyu Kwon, Doyoun Kim, Woong Sun, Jin Young Kim, Kihoon Han (2022).

Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion

J. Neurochem. 2022 May 14. doi: 10.1111/jnc.15622. Online ahead of print

27. Hong-Jae Lee, Dong-Min Lee, Min-Ji Seo, Ho-Chul Kang, Seok-Kyu Kwon, Kyeong-Sook Choi (2022)

PSMD14 Targeting Triggers Paraptosis in Breast Cancer Cells by Inducing Proteasome Inhibition and Ca2+ Imbalance

Int. J. Mol. Sci. 2022 Feb 28;23(5):2648. doi: 10.3390/ijms23052648.

26. Chanmin Park, Kanggeun Lee, Su Yeon Kim, Fatma Sema Canbakis Cecen, Seok-Kyu Kwon, Won-Ki Jeong (2021)

Neuron Segmentation using Incomplete and Noisy Labels via Adaptive Learning with Structure Priors

2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI).

Doi: 10.1109/ISBI48211.2021.9434102

25. Chunmei Jin, Hyojin Kang, Taesun Yoo, Jae Ryun Ryu, Ye-Eun Yoo, Ruiying Ma, Yinhua Zhang, Hyae Rim Kang, Yoonhee Kim, Hyunyoung Seong, Geul Bang, Sangwoo Park, Seok-Kyu Kwon, Woong Sun, Hyunkyung Kim, Jin Young Kim, Eunjoon Kim and Kihoon Han

The Neomycin Resistance Cassette in the Targeted Allele of Shank3B Knock-Out Mice Has Potential Off-Target Effects to Produce an Unusual Shank3 Isoform

Front. Mol. Neurosci., 2021 Jan 11;13:614435. doi: 10.3389/fnmol.2020.614435

24. Yinhua Zhang, Hyae Rim Kang, Seung-Hyun Lee, Yoonhee Kim, Ruiying Ma, Chunmei Jin, Ji-Eun Lim, Seoyeon Kim, Yeju Kang, Hyojin Kang, Su Yeon Kim, Seok-Kyu Kwon, Se-Young Choi and Kihoon Han

Enhanced Prefrontal Neuronal Activity and Social Dominance Behavior in Postnatal Forebrain Excitatory Neuron-Specific Cyfip2 Knock-Out Mice

Front. Mol. Neurosci., 2020 Oct 29;13:574947. doi: 10.3389/fnmol.2020.574947

23. Chan E Park, Youngbin Cho, In Cho, Hyunsu Jung, Byeongyeon Kim, Jennifer H. Shin, Sungyoung Choi, Seok-Kyu Kwon*, Young Ki Hahn*, and Jae-Byum Chang* (* co-corresponding author)

Super-Resolution Three-Dimensional Imaging of Actin Filaments in Cultured Cells and the Brain via Expansion Microscopy

ACS Nano 2020, 2020, 14, 11, 14999–15010. Publication Date:October 23, 2020

https://doi.org/10.1021/acsnano.0c04915

22. Hyunsu Jung, Su Yeon Kim, Fatma Sema Canbakis Cecen, Yongcheol Cho, and Seok-Kyu Kwon*

Dysfunction of mitochondrial Ca2+ regulatory machineries in brain aging and neurodegenerative diseases

Frontiers in Cell and Developmental Biology, 2020; 8: 599792.

doi: 10.3389/fcell.2020.599792

21. Gyu Hyun Kim, Yinhua Zhang, Hyae Rim Kang, Seung-Hyun Lee, Jiwon Shin, Chan Hee Lee, Hyojin Kang, Ruiying Ma, Chunmei Jin, Yoonhee Kim, Su Yeon Kim, Seok-Kyu Kwon, Se-Young Choi, Kea Joo Lee, Kihoon Han

Altered presynaptic function and number of mitochondria in the medial prefrontal cortex of adult Cyfip2 heterozygous mice

Mol Brain. 2020; 13: 123. Published online 2020 Sep 11. doi: 10.1186/s13041-020-00668-4

20. Kim H, Jung H, Jung H, Kwon SK, Ko J, Um JW.

The small GTPase ARF6 regulates GABAergic synapse development

Mol Brain. 2020 Jan 6;13(1):2. doi: 10.1186/s13041-019-0543-3.

19. Rangaraju V, Lewis TL Jr, Hirabayashi Y, Bergami M, Motori E, Cartoni R, Kwon SK*, Courchet J*. (2019) (* co-corresponding author)

Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease

J. Neuroscience. 2019 Oct 16;39(42):8200-8208

18. Lewis TL*, Kwon SK*, Lee A, Shaw R, and Polleux F. (2018)

(* co-first author)

MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size

Nature Communications 9, Article number: 5008 (2018)

17. Lee A*, Hirabayashi Y*, Kwon SK*, Lewis TL* and Polleux F. (2018) (*co-first author)

Emerging roles of mitochondria in synaptic transmission and neurodegeneration

Curr. Op. in Physiol. (2018)

16. Hirabayashi Y*, Kwon SK*, Paek H, Pernice W, Paul MA, Lee J, Erfani P, Raczkowski A, Petrey DS, Liza A. Pon LA and Polleux F. (2017)

(* co-first author)

ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons

Science 358, 623–630 (2017)

15. Bae YS, Yoon SH, Han JY, Woo J, Cho Y, Kwon SK, Bae YC, Kim D, Kim E and Kim MH. (2017)

Deficiency of aminopeptidase P1 causes behavioral hyperactivity, cognitive deficits, and hippocampal neurodegeneration

Genes, Brain, and Behavior. 2017 Aug 23. doi: 10.1111/gbb.12419

14. Lewis TL, Gergely FT, Kwon SK, Losonczy A and Polleux F. (2016)

Progressive decrease of mitochondrial motility during maturation of cortical axons in vitro and in vivo

Current Biology. 26(19):2602-2608 (2016)

13. Kwon SK, Hirabayashi Y and Polleux F. (2016)

Organelle-specific sensors for monitoring Ca2+ dynamics in neurons

Front. Synaptic Neurosci. doi: 10.3389/fnsyn.2016.00029

12. Kwon SK, Sando R, Lewis TL, Hirabayashi Y, Maximov A and Polleux F. (2016)

LKB1 regulates mitochondria-dependent presynaptic calcium clearance and neurotransmitter release properties at excitatory synapses along cortical axons

PLoS Biology. 14(7):e1002516 (2016)

11. Choi Y, Nam J, Whitcomb DJ, Song YS, Kim D, Jeon S, Um JW, Lee SG, Woo J, Kwon SK, Li Y, Mah W, Kim HM, Ko J, Cho K and Kim E. (2016).

SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development.

Scientific Reports 6: 26676 (2016)

10. Jang S, Oh D, Lee Y, Hosy E, Shin H, Riesen C, Whitcomb D, Warburton JM, Jo J, Kim D, Kim SG, Um SM, Kwon SK, Kim MH, Roh JD, Woo J, Jun H, Lee D, Mah W, Kim H, Kaang BK, Cho K, Rhee JS, Choquet D and Kim E. (2016)

Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity

Nature Neuroscience. 19(1):84-93

9. Baek ST, Copeland B, Yun EJ, Kwon SK, Guemez-Gamboa A, Schaffer AE, Kim S, Kang HC, Song S, Mathern GW and Gleeson JG. (2015)

An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development

Nature Medicine. 21:1445-1454

8. Woo J*, Kwon SK*, Nam JY*, Choi SW*, Takahashi H*, Krueger D, Park JH, Bae JY, Ko JW, Lee DM, Kim H, Kim MH, Bae YC, Chang SH, Craig AM and Kim E. (2013)

(* co-first author)

IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development.

Journal of Cell Biology, 201:929-944

7. Yoon KJ, Lee HR, Jo YS, An K, Jung SY, Jeong MW, Kwon SK, Kim NS, Jeong HW, Ahn SH, Kim KT, Lee K, Kim E, Kim JH, Choi JS, Kaang BK and Kong YY. (2012)

Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway.

Molecular Brain 5:40

6. Kwon SK*, Woo J*, Kim SY, Kim H and Kim E. (2010). (* co-first author)
Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, PTPδ, and PTPσ via specific domains regulate excitatory synapse formation.

J. Biol. Chem. 285:13966-13978

5. Lim SH, Kwon SK, Lee MK, Moon J, Jeong DG, Park E, Kim SJ, Park BC, Rhu SE, Yu DY, Kim E, Myung PK, and Lee JR. (2009).
Regulation of synapse formation by PTPRT through interaction with cell adhesion molecules and Fyn.
The EMBO Journal 28: 3564 - 3578

4. Woo J*, Kwon SK* and Kim E. (2009). (* co-first author).The NGL family of leucine-rich repeat-containing synaptic adhesion molecules.Mol. Cell. Neuroscience 42:1-10.

3. Woo J*, Kwon SK*, Choi S, Kim S, Lee JR, Dunah AW, Sheng M and Kim E. (2009).

(*co-first author)

Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses.

Nature Neuroscience 12:428-437.

2. Kim Y, Park J, Kim S, Song S, Kwon SK, Lee SH, Kitada T, Kim JM and Chung J. (2008)
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.
Biochem Biophys Res Commun. 377(3):975-80.

1. Kim S, Burette A, Chung HS, Kwon SK, Woo J, Lee HW, Kim K, Kim H, Weinberg RJ and Kim E. (2006).

NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation.

Nature Neuroscience 9:1294-1231.